Chemo-immunological Studies on Conjugated Carbohydrate-proteins

Chemo-immunological Studies on Conjugated Carbohydrate-proteins Viii. the Influence of the Acetyl Group on the Specificity

Chemo-immunological Studies on Conjugated Carbohydrate-proteins v. the Immunological Specificity of an Antigen Prepared by Combining the Capsular Polysaccharide of Type Iii Pneumococ~us with Foreign Protein by Oswald

The fundamental studies of Landsteiner and his coworkers (1) on complex antigens have established the important principle that the introduction into the protein molecule of a simple non-protein radical confers a new immunological specificity on the antigenic compound. Furthermore, this newly acquired specificity has been shown to depend upon the nature of the new chemical grouping thus introduc...

Chemo-immunological Studies on Conjugated Carb Ohyd Rate -proteins Xii. the Immunological Properties Oy an Art~icial Antio~.n

Chemo-immunological Studies on Conjugated Carbohydrate-proteins Ii. Immunological Specificity of Synthetic Sugar-protein Antigens

The function of carbohydrates as determinative substances in bacterial specificity is well illustrated in the immunological differentiation of thespecific types of pneumococci and of Friedlander bacilli. Previous studies have demonstrated that the presence of type-specific polysaccharides in these encapsulated organisms determines the antigenic properties of the cell and the serological relatio...

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARB OHY DRATE-PROTEINS IX . THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THE p-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN BY WALTHER F. GOEBEL, ProD.,

As a result of the work of numerous investigators a striking advance has been made during the past decade in our knowledge of the chemical and immunological properties of that unique class of naturally occurring substances, the specific bacterial polysaccharides. Complex carbohydrates possessing immunologically specific properties have been found widely distributed in many varieties of differen...

Chemo-immunological Studies on Conjugated Carbohydrate-proteins Iii. Active and Passive An- with %nth3ztic Ugar- Proteins

In the first of these communications Goebel and Avery (1) described the chemical methods by means of ‘which the p-aminophenol ghxosides were synthesized from glucose and galactose and the dia&aed substances bound to protein. The two newly synthesized sugar-proteins d&r from one another chemically only in specific rotation and molecular co~tion. In the second paper, Avery and Goebel(2) reported ...